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M94A0313.TXT
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1994-10-08
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Document 0313
DOCN M94A0313
TI Stroke and cerebral infarcts in children infected with human
immunodeficiency virus.
DT 9412
AU Philippet P; Blanche S; Sebag G; Rodesch G; Griscelli C; Tardieu M;
Service of Pediatric Immunology and Hematology, Hopital; Necker-Enfants
Malades, Paris, France.
SO Arch Pediatr Adolesc Med. 1994 Sep;148(9):965-70. Unique Identifier :
AIDSLINE MED/94356160
AB OBJECTIVE: To study the causes of stroke and cerebral infarcts in
children infected with the human immunodeficiency virus (HIV)-type 1.
DESIGN: Case series. PATIENTS: Four of 380 HIV-infected children
followed up in a 10-year period in our department who had a stroke with
evidence of cerebral infarcts on radiological imaging. RESULTS: The four
patients were severely immunodepressed, but their clinical status and
outcome were different. Aneurysmal dilation of major cerebral arteries
and thrombosis of these arteries or of small cortical vessels were
discovered in two patients. Both patients had a history of frequent
infections and had suffered repeated neurological events that resulted
in severe clinical deterioration or death. An infectious causative agent
was strongly suspected but was not detected. The other two patients had
a more favorable outcome. An isolated cerebrovascular thrombosis was
found in one patient, while in the other, HIV-1-related focal necrosis
was suggested by the lack of permanent cerebrovascular abnormalities or
thrombosis and by signs of necrosis in biopsy specimens of the brain.
CONCLUSION: Stroke and cerebral infarcts in HIV-1 infected children have
different causes and different prognoses.
DE Adolescence Antigens, CD4 Brain/PATHOLOGY Case Report Cerebral
Infarction/*ETIOLOGY/PATHOLOGY Cerebrovascular
Disorders/*ETIOLOGY/RADIOGRAPHY Child Child, Preschool Fatal Outcome
Female Follow-Up Studies Human HIV Infections/*COMPLICATIONS *HIV-1
Magnetic Resonance Imaging Male Prognosis Tomography, X-Ray Computed
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).